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KMID : 1197720140070020095
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대한파킨슨병 및 이상운동질환 학회지
2014 Volume.7 No. 2 p.95 ~ p.98
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Treatment of Gait Ignition Failure with Ropinirole
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Cohen-Oram Alexis N.
Stewart Jonathan T.
Kim Bero
Hoffmann Michael W.
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Abstract
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Gait ignition failure (GIF) is a syndrome characterized by hesitation or inability to initiate gait from a static position. It may occur in a variety of conditions, including normal pressure hydrocephalus, subcortical vascular disease, parkinsonian syndromes and a variety of focal lesions. Previous information on the treatment of GIF has been primarily anecdotal, but there have been a few reports of response to dopamine agonists. We report a 63-year-old man with anoxic encephalopathy who developed GIF nine years after the initial anoxic insult. The patient’s GIF responded robustly, albeit transiently, to ropinirole. MRI was unrevealing, but a positron emission tomography scan showed hypometabolism in the deep frontal ACA/MCA watershed area; this may have disconnected the basal ganglia from the motor cortex and/or interrupted dopaminergic mesocortical transmission. Our understanding of the pathophysiology and the treatment of GIF remains limited, but there may be at least a limited therapeutic role for dopamine agonists.
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KEYWORD
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Gait, Gait ignition failure, Dopamine agonists, Ropinirole, Anoxic encephalopathy
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Listed journal information
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